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droxicam
- Development stage
- Discontinued
- Lead developer
- Esteve
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Droxicam is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class and acts as a prodrug of piroxicam. It was developed to improve the gastric tolerability of piroxicam. After oral administration, droxicam is hydrolyzed in the digestive tract to its active form, piroxicam. Its primary mechanism of action is inhibition of prostaglandin biosynthesis via inhibition of prostaglandin synthase (cyclooxygenase), leading to reduced pain and inflammation. Droxicam was used for relief in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis but has been withdrawn in many countries due to hepatotoxicity[1][3][4][5].
- Brand names
- DobenamDroflexDrogelonDroxarFerpanPrecam
- Other names
- droxicam
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)
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