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DRT102-sp
- Development stage
- Preclinical
- Lead developer
- Darnatein
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Implant
01
Overview
DRT102-sp is an engineered bone morphogenetic protein (BMP) biobetter in the design and concept stages of development by OSR Holdings and its subsidiary, Darnatein. Utilizing the proprietary DA-BMP (Darnatein-BMP) platform, the asset is designed to enhance BMP pathway activity to support bone and spinal regeneration. The program is currently being explored for orthopedic and dental applications, including lumbar stenosis, disc herniation, spinal fusion, dental augmentation, and non-union bone fractures. It represents an earlier-stage iteration or specialized version of the core DRT-102 program, focusing on targeted bone growth and structural repair.
- Other names
- DRT102-spDRT-102-spDRT 102-spDA-BMP
02
Targets
BMPR2 (Bone morphogenetic protein receptor type II)ACVR1 (Activin receptor type I)BMP1 (Bone morphogenetic protein 1)ACVR2A (Activin receptor type 2A)
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