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drynaria rhizome extract
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Drynaria rhizome extract is a herbal preparation derived from the rhizomes of *Drynaria fortunei*, a fern widely used in Traditional Chinese Medicine (TCM) for bone-related conditions such as osteoporosis and fractures. Recent research indicates its potential in managing metabolic disorders. It functions by activating the adenosine monophosphate-activated protein kinase (AMPK) pathway, which in turn downregulates lipogenic transcription factors like sterol regulatory element-binding protein-1 (SREBP-1) and peroxisome proliferator-activated receptor-gamma (PPAR-γ). This mechanism leads to reduced lipid accumulation in the liver and adipose tissue, suggesting a dual role in bone health and obesity management.
- Brand names
- Qianggu Capsule强骨胶囊
- Other names
- Drynaria fortunei extractGu-Sui-Bu extractDrynariae Rhizoma extract
02
Targets
PPARG (Peroxisome proliferator-activated receptor gamma)AMPK (Adenosine monophosphate–activated protein kinase)SREBP-1 / SREBF1 (SREBP-1)CHUK (IKKα)
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