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DS-8201-ICG
- Development stage
- Preclinical
- Lead developer
- Daiichi Sankyo
- Modality
- Light/Condition-Responsive Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
**DS-8201-ICG** is an investigational HER2-targeted near-infrared-II fluorescent theranostic probe constructed by conjugating trastuzumab deruxtecan with indocyanine green. The construct is intended to retain HER2-directed tumor binding while enabling deep-tissue fluorescence imaging, intraoperative tumor-margin delineation, and detection of small HER2-positive breast-cancer lesions. In an orthotopic mouse model, DS-8201-ICG produced tumor-selective NIR-II fluorescence after administration and was studied as a potential imaging-guided strategy for HER2-positive breast cancer, including trastuzumab deruxtecan-resistant disease.
- Other names
- DS-8201-ICGDS8201-ICGDS 8201-ICG
02
Targets
TOP1 (DNA Topoisomerase I)ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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