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DSG2-directed CAR-T cells are a type of chimeric antigen receptor T cell therapy targeting desmoglein 2 (DSG2), a cadherin protein. This investigational therapy is designed to target cells expressing DSG2, which modulates cell growth, survival, and metastasis. The therapy involves engineering a patient's own T cells to express a receptor that recognizes DSG2, potentially enabling them to identify and attack cells expressing this target.
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