dsp-4

DSP-4 is a **highly selective neurotoxin** that acts selectively on the noradrenergic neurons of the central and peripheral nervous system, especially those originating from the locus coeruleus[2][4][6][7]. It is used primarily in research settings for the **temporary selective degradation of noradrenergic neurons**, allowing study of noradrenergic function. DSP-4 readily crosses the blood-brain barrier and exerts neurotoxic effects by destroying noradrenergic nerve terminals, resulting in marked depletion of norepinephrine in selected areas of the brain[2][7]. Its mechanism is based on selective uptake by noradrenergic neurons via the norepinephrine transporter, leading to intracellular toxicity and degeneration of these neurons[2][7]. DSP-4 is not approved for human therapeutic use and is strictly limited to research applications. There is no documented original developer; it is commonly supplied by multiple chemical suppliers for laboratory use[2][3][4][5][6]. Primary indications are neurobiological research into adrenergic systems and associated disorders.

Other names

DSP-4DSP4DSP 4Neurotoxin DSP 4 hydrochlorideN-(2-bromobenzyl)-2-chloro-N-ethylethanamine hydrochloride2-Bromo-N-(2-chloroethyl)-N-ethylbenzenemethanamineN-(2-chloroethyl)-N-ethyl-2-bromobenzylamineUNII-PQ1P7JP5C1UNII-PQ-1P7JP5C1UNII-PQ 1P7JP5C1