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DSP107
- Development stage
- Phase 2
- Lead developer
- KAHR Medical
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
DSP107 is a bi-functional, trimeric fusion protein composed of the extracellular domains of SIRPα and 4-1BBL. It is designed to target cancer by simultaneously blocking the CD47/SIRPα "don't eat me" signaling axis on phagocytes—thereby promoting innate anticancer immunity—and activating the costimulatory receptor 4-1BB (CD137) on T cells, which augments adaptive anticancer immunity. By binding both cancer cells (via CD47) and immune cells (via 4-1BB), DSP107 combines checkpoint inhibition with tumor-localized immune cell activation, leading to targeted macrophage and T-cell mediated tumor destruction. The drug is being developed primarily for use in various cancers, including advanced solid tumors, acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and diffuse large B-cell lymphoma (DLBCL).
- Other names
- SIRPα-4-1BBL
02
Targets
TNFRSF9 (CD137 extracellular domain)CD47 (Cluster of Differentiation 47)
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