DSPE-DOTA-Gd

DSPE-DOTA-Gd is a gadolinium-based contrast agent designed for use in magnetic resonance imaging (MRI). It consists of a lipid derivative (1,2-distearoyl-sn-glycero-3-phosphoethanolamine or DSPE) conjugated to DOTA (1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid), which acts as a chelator for gadolinium ions (Gd3+). The resulting compound can be incorporated into liposomes or lipid nanoparticles to create MRI-detectable formulations with high relaxivity and stability. This design allows for enhanced imaging contrast and site-targeted delivery in molecular imaging studies. The agent has been shown to have high longitudinal relaxivity and low risk of transmetallation with other metal ions such as zinc, contributing to its biocompatibility. It is being investigated primarily as an MRI enhancer for applications including molecular imaging and targeted drug delivery[1][2][4][7].

Other names

Gd(III)DOTA-DSPEDSPE-DOTA-Gd(III)Gadolinium ion chelated DSPE-DOTA