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DT-EBVcom

Development stage: Preclinical
Lead developer: Calder Biosciences
Modality: Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration: Parenteral

Overview

DT-EBVcom is a preclinical protein-based combination vaccine developed by Calder Biosciences for the prevention and treatment of Epstein-Barr Virus (EBV) infection and its associated conditions, including infectious mononucleosis, malignancies, and autoimmune diseases. The vaccine utilizes Calder's proprietary 3D-Vaxlock technology to stabilize the prefusion conformations of the EBV envelope glycoprotein complex gB and gH/gL. By combining these stabilized antigens with the EBV gp350 protein, DT-EBVcom aims to elicit a potent and broad neutralizing antibody response that targets multiple stages of the viral entry process into B cells and epithelial cells.

Other names: Epstein-Barr Prefusion gB + gH/gL LockedLocked DT-EBVcom

Targets

Epstein–Barr virus envelope glycoprotein gBEpstein–Barr virus envelope glycoprotein H/glycoprotein L complexgp350 (Epstein-Barr virus glycoprotein 350)

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