dTAGv1

dTAGv1 is a heterobifunctional small molecule degrader used in the degradation TAG (dTAG) system to induce the rapid and specific degradation of proteins fused to a mutant FKBP12 (F36V) tag. Developed by the Bradner lab at the Dana-Farber Cancer Institute, dTAGv1 acts as a molecular bridge between the FKBP12(F36V)-tagged target protein and the Cereblon (CRBN) E3 ubiquitin ligase complex, leading to polyubiquitination and subsequent proteasomal degradation of the fusion protein. This system is primarily used as a research tool for functional genomics and target validation, allowing for acute protein depletion to study immediate biological effects, such as identifying transcriptional targets of oncogenic drivers like NSD2 in multiple myeloma.

Other names

dTAG-1dTAG1dTAG 1