Drug intelligence / Profile preview

DTaP-IPV-Hep B-PRP~T vaccine

Development stage
Approved
Lead developer
Sanofi
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

DTaP-IPV-Hep B-PRP~T vaccine (brand name: Hexaxim) is a fully liquid, hexavalent combination vaccine developed by Sanofi Pasteur. It is designed for primary and booster vaccination of infants and young children against six major infectious diseases: diphtheria, tetanus, pertussis (whooping cough), poliomyelitis, hepatitis B, and invasive diseases caused by Haemophilus influenzae type b (Hib). The vaccine contains diphtheria and tetanus toxoids, a two-component acellular pertussis (aP) component (pertussis toxoid and filamentous haemagglutinin), recombinant hepatitis B surface antigen (HBsAg), inactivated poliovirus (IPV) types 1, 2, and 3, and Hib capsular polysaccharide (PRP) conjugated to tetanus protein (PRP~T). A key advantage of this formulation is that it is fully liquid and ready to use, eliminating the need for reconstitution of the Hib component, which simplifies administration and reduces the risk of errors.

Brand names
HexaximHexyonHexacima
Other names
Hexavalent DTPa-HepB-IPV-Hib vaccineDTaP-IPV-HB-Hib vaccinediphtheria, tetanus, pertussis (acellular, component), hepatitis B (rDNA), poliomyelitis (inactivated) and haemophilus type b conjugate vaccine (adsorbed)
02

Targets

PRNP (Cellular Prion Protein)FHA (Filamentous hemagglutinin)HBsAg (Hepatitis B surface antigen)TT (Tetanus toxoid)

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