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Duanteng-Yimu Tang
- Development stage
- Preclinical
- Lead developer
- Guangzhou University of Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Duanteng-Yimu Tang (DTYMT) is a Traditional Chinese Medicine (TCM) decoction primarily investigated for its therapeutic effects on rheumatoid arthritis (RA). The formula is a combination of *Tripterygium wilfordii* Hook. f. (Duanteng) and *Leonurus japonicus* Houtt. (Yimucao). It functions by modulating the immune system, specifically targeting the imbalance between regulatory T cells (Treg) and Th17 cells, which is a hallmark of RA pathogenesis. By increasing Treg populations and decreasing Th17 activity, DTYMT reduces the secretion of pro-inflammatory cytokines such as IL-17, TNF-alpha, and IL-6. This action helps to suppress synovial inflammation, reduce cartilage destruction, and improve clinical outcomes in patients with RA who may not respond adequately to conventional disease-modifying antirheumatic drugs (DMARDs).
- Other names
- Duanteng-Yimu Decoction
02
Targets
IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))
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