DUB-IN-2

DUB-IN-2 is a potent small molecule inhibitor of deubiquitinating enzymes (DUBs), specifically targeting ubiquitin-specific protease 8 (USP8) with an IC50 of 0.28 μM and ubiquitin-specific protease 7 (USP7) with an IC50 of 7.2 μM. Belonging to the 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile chemical class, it serves as a valuable research tool for investigating the ubiquitin-proteasome system's role in cancer and cell cycle regulation. Preclinical research has demonstrated that DUB-IN-2 can reduce EGFR protein expression in corticotroph tumor cells and downregulate PD-L1 levels in pancreatic cancer models by promoting their ubiquitination and subsequent proteasomal degradation. This mechanism has been shown to sensitize tumor cells to anti-PD-L1 immunotherapy. DUB-IN-2 is currently intended for laboratory research purposes only and is not in clinical development.

Other names

DUBs-IN-2DUBs-IN2DUBs-IN 2