Drug intelligence / Profile preview

Duhuo Jisheng Tang

Development stage
Unknown
Lead developer
Sun Ten
Administration
Oral
01

Overview

Duhuo Jisheng Tang (DHJST) is a classic Traditional Chinese Medicine (TCM) herbal formula widely used for the treatment of chronic inflammatory conditions, particularly rheumatoid arthritis (RA) and osteoarthritis. It is traditionally indicated for Bi-syndrome characterized by liver and kidney deficiency and wind-cold-dampness. The formula typically consists of 15 medicinal herbs, including *Angelica pubescens* and *Taxillus chinensis*. Modern pharmacological studies suggest that DHJST exerts anti-inflammatory, analgesic, and immunomodulatory effects by inhibiting pro-inflammatory cytokines (such as TNF-alpha and IL-1beta) and regulating the RANKL/OPG signaling pathway. Recent clinical research, such as that conducted by Longhua Hospital, explores its role in improving lymphatic drainage to reduce joint swelling and disease activity in RA patients.

Brand names
Duhuo Jisheng DecoctionDuhuo Jisheng TangDuhuo Jisheng WanDuhuo Jisheng Pill
Other names
Duhuo Parasitic DecoctionDHJSTDu-Huo-Ji-Sheng-Tang
02

Targets

RANKL (Receptor Activator for Nuclear Factor-kappa B Ligand)IL1B (Interleukin-1 beta)

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