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Drug intelligence / Profile preview
duloxetine + opioid
- Development stage
- Unknown
- Lead developer
- Eli Lilly
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Transdermal, Intramuscular, Subcutaneous, Intrathecal
01
Overview
A combination therapy using duloxetine (a serotonin-norepinephrine reuptake inhibitor) and opioid medications for pain management. This combination is primarily used for treating various pain conditions, particularly postoperative pain and cancer-related neuropathic pain. The dual mechanism targets both monoamine reuptake inhibition and opioid receptor activation to provide pain relief.
02
Targets
DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)MOR (Mu opioid receptor)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)
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