duloxetine vs. escitalopram

Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) used primarily for the treatment of major depressive disorder, generalized anxiety disorder, and certain types of pain such as neuropathic pain and fibromyalgia. It works by inhibiting the reuptake of both serotonin and norepinephrine in the central nervous system, thereby increasing their levels and enhancing neurotransmission[1][5][8]. Escitalopram is a selective serotonin reuptake inhibitor (SSRI) indicated for major depressive disorder and generalized anxiety disorder. It selectively inhibits the serotonin transporter (SERT), leading to increased synaptic concentrations of serotonin. Escitalopram also binds to an allosteric site on SERT, which may further modulate its activity[6]. Both drugs are prescription antidepressants with established efficacy in depression and anxiety disorders; duloxetine has broader FDA-approved uses including pain syndromes, while escitalopram is noted for its high selectivity for SERT and generally favorable tolerability profile[3][5].

Brand names

CymbaltaDrizalma SprinkleIrenkaLexapro