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Dun Ye Guan Xin Ning
- Development stage
- Unknown
- Lead developer
- ChiaTai Qingchunbao Pharmaceutical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Dun Ye Guan Xin Ning is a Traditional Chinese Medicine (TCM) product derived from the rhizome of *Dioscorea zingiberensis* C.H. Wright. It is primarily indicated for the treatment of coronary artery disease (CAD) and stable angina pectoris. The therapeutic effect is attributed to its high content of steroidal saponins, particularly diosgenin-type saponins, which possess potent anti-platelet and vasodilatory properties. By inhibiting platelet aggregation and relaxing vascular smooth muscle, the drug enhances coronary blood flow and reduces myocardial oxygen consumption. It is manufactured as a tablet and has been the subject of clinical registries in China to evaluate its efficacy across various patient subgroups.
- Brand names
- Dun Ye Guan Xin Ning
- Other names
- Dunye Guanxinning盾叶冠心宁
02
Targets
EGFR T790M (Epidermal growth factor receptor T790M mutant)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)MAPK14 (p38 mitogen-activated protein kinase alpha)
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