Drug intelligence / Profile preview

Duonika

Development stage
Unknown
Lead developer
Valenta Pharm
Modality
Small Molecules
Administration
Oral
01

Overview

Duonika is a combined oral contraceptive (COC) developed and marketed by Valenta Pharmaceuticals. It is a small molecule combination therapy consisting of drospirenone, a fourth-generation progestogen, and ethinylestradiol, a synthetic estrogen. Drospirenone is unique among progestogens for its pharmacological profile, which closely mimics natural progesterone, possessing anti-mineralocorticoid and anti-androgenic activities. These properties help to counteract estrogen-related sodium retention and treat androgen-dependent conditions like acne. Duonika is primarily indicated for the prevention of pregnancy, but it is also utilized for the treatment of moderate acne vulgaris and the management of symptoms associated with premenstrual dysphoric disorder (PMDD) in women who opt for oral contraception.

Brand names
Duonika
Other names
drospirenone + ethinylestradiolДуоника
02

Targets

MR (Mineralocorticoid receptor)ER (Estrogen receptor)PR (Progesterone receptor)AR (Adrenergic receptors)

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