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DuoSTAR KRAS gene editing program
- Development stage
- Preclinical
- Lead developer
- GeneLancet Biosciences
- Modality
- CRISPR-Cas9 → CRISPR Systems → Programmable Nucleases → Gene Editing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
GeneLancet Biosciences is developing a broad-spectrum gene editing therapeutic program using their proprietary DuoSTAR (STAR editor) technology to target multiple KRAS oncogenic mutations, including G12D, G12C, G12V, G13A, and G13C variants. The STAR (Seek -> Tag -> Amend -> Release) editor is a precise multiple-turnover genome editing platform that uses ligated guide RNAs (LgRNA) and a modified Cas9 protein to edit and inactivate KRAS mutations in cancer cells. This gene editing modality is designed as a broad-spectrum therapeutic agent to treat a wide range of KRAS-driven cancers by inserting stop codons to ensure minimal truncated protein byproducts, potentially offering a one-time cure for various oncology indications.
- Other names
- KRAS broad-spectrum therapeutic programCancer Program
02
Targets
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