Duostatin 5

Duostatin 5 (Duo-5) is a potent small-molecule cytotoxin and a derivative of monomethyl auristatin F (MMAF). It acts as a microtubule inhibitor by binding to tubulin and inhibiting its polymerization, which leads to cell cycle arrest and apoptosis in rapidly dividing cancer cells. Duostatin 5 is specifically designed for use as a payload in antibody-drug conjugates (ADCs). It is typically conjugated to targeting antibodies using site-specific technologies, such as the C-LOCK (interchain cysteine cross-linking) conjugation method. Notable ADC candidates utilizing Duostatin 5 include STI-6129, which targets CD38 for the treatment of multiple myeloma and AL amyloidosis, and ZV05, which targets the 5T4 oncofetal antigen.

Other names

Duostatin-5Duostatin5Duostatin 5