Drug intelligence / Profile preview

DuraGraft

Development stage
Unknown
Lead developer
Marizyme
Modality
Small Molecules
Administration
Irrigation
01

Overview

DuraGraft is a one-time intraoperative vascular graft treatment and preservation solution developed by Somahlution (acquired by Marizyme). It is designed to protect vascular grafts, such as the saphenous vein harvested during coronary artery bypass grafting (CABG), from oxidative stress and endothelial injury during the ischemic period between harvesting and revascularization. The solution contains a combination of active ingredients including L-glutathione, L-ascorbic acid, and L-arginine. It has received FDA De Novo clearance as a Class II medical device/solution for use in CABG and is being investigated for broader applications in organ transplant preservation (kidney, liver, and heart) and myocardial protection.

Brand names
DuraGraft
Other names
GALASOMVC001SOMVC-001SOMVC 001
02

Targets

NOS1 (nNOS)

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