Drug intelligence / Profile preview

duraphat fluoride varnish

Development stage
Phase 4
Lead developer
Colgate-Palmolive
Modality
Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems
Administration
Dental, Topical
01

Overview

Duraphat Fluoride Varnish is a topical dental preparation containing 5% w/v sodium fluoride (50 mg/mL), equivalent to 22,600 ppm (22.6 mg) of fluoride ion per mL in an alcoholic solution of natural resins[1][2][3][4]. It is applied professionally to the teeth as a thin layer for the prevention of dental caries and for the desensitization of hypersensitive teeth. The mechanism involves formation of calcium fluoride globules on tooth surfaces; these act as a reservoir that slowly releases fluoride ions, promoting remineralization and inhibiting demineralization by cariogenic acids[2][3]. The product is indicated for both children and adults as part of comprehensive caries control programs or treatment regimens for dentine hypersensitivity. It should be applied by dental professionals only.

Brand names
Duraphat Fluoride VarnishColgate Duraphat VarnishDuraphat
Other names
sodium fluoride dental suspension 50 mg/mLsodium fluoride varnish 5%
02

Targets

Dental plaque (Oral biofilm)

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