Drug intelligence / Profile preview

durvalumab + exemestane

Development stage: Unknown
Lead developer: AstraZeneca
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration: Intravenous, Oral

Overview

Durvalumab + exemestane is a combination therapy being investigated for the treatment of hormone receptor-positive breast cancer. Durvalumab is an immune checkpoint inhibitor that targets PD-L1, while exemestane is an aromatase inhibitor that reduces estrogen production. This combination aims to provide dual-action treatment by combining immunotherapy with hormonal therapy.

Targets

CD274 (Programmed cell death protein 1 ligand 1)CYP19A1 (Aromatase)

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