Drug intelligence / Profile preview

dust mite mixture (Wolwo Biotech)

Development stage
Preclinical
Lead developer
Eye and ENT Hospital of Fudan University
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Sublingual
01

Overview

**Dust mite mixture** is a sublingual allergen immunotherapy preparation comprising allergenic material from *Dermatophagoides farinae* and *Dermatophagoides pteronyssinus* with a pharmaceutically acceptable carrier. Repeated controlled sublingual exposure is intended to induce allergen-specific immune tolerance and reduce IgE-mediated respiratory-allergy symptoms. The exact Chinese name, 尘螨合剂, is described in a Chinese patent for treatment of allergic diseases and was evaluated in the registered multicenter, randomized, double-blind, placebo-controlled ChiCTR-IIR-17013839 study for allergic rhinitis, with allergic asthma also represented in the trial context. ([europepmc.org](https://europepmc.org/patents/PAT/CN1840189))

Other names
dust mite allergen mixture尘螨合剂
02

Targets

TCR-HDM-pMHCII (T cell receptor recognizing house dust mite-derived peptide-MHC class II complexes)BCR (Immunoglobulin G B Cell Receptor)CD23 (Low affinity immunoglobulin epsilon Fc receptor)

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