Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
DV-PE-Fc
- Development stage
- Preclinical
- Lead developer
- Institute of Science Tokyo
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
01
Overview
DV-PE-Fc is a proteolysis-resistant, Fc-tagged mutant of domain V (DV) of beta-2-glycoprotein I (β2GPI). It is designed as a decoy therapeutic agent for antiphospholipid antibodies (aPLs) to prevent and treat thrombosis in patients with antiphospholipid syndrome (APS) and catastrophic antiphospholipid syndrome (CAPS). By competitively inhibiting the binding of pathogenic aPLs to the β2GPI/cardiolipin complex, DV-PE-Fc suppresses complement activation and tissue factor expression, thereby preventing multiorgan thrombosis without increasing bleeding risk. The Fc tag extends the drug's half-life and increases its stability in circulation.
- Other names
- domain V mutant-Fc fusion proteinproteolysis-resistant Fc-tagged DV mutantproteolysis-resistant Fc-tagged domain V mutant
02
Targets
PS (Phosphatidylserine)B2GP1 (Beta-2-glycoprotein I)aPL (Antiphospholipid antibodies)
Beyond the preview
Go deeper on DV-PE-Fc.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on DV-PE-Fc.