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DWP431
- Development stage
- Preclinical
- Lead developer
- Daewoong Pharmaceutical
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Implant
01
Overview
DWP431 is a biopharmaceutical candidate consisting of recombinant human Bone Morphogenetic Protein-2 (rhBMP-2), developed by Daewoong Pharmaceutical in collaboration with Great Bear Pharmaceutical. It is specifically designed for use in spinal fusion procedures to promote bone growth and stabilization. As an osteoinductive protein, DWP431 stimulates the recruitment and differentiation of mesenchymal stem cells into bone-forming osteoblasts. The product is typically delivered via a carrier, such as a hydroxyapatite or collagen scaffold, to the site of surgery. DWP431 is the development code for the version of Daewoong's BMP-2 technology (marketed as Novosis in South Korea) being advanced for clinical use and regulatory approval in the United States and Japan.
- Brand names
- Novosis
- Other names
- recombinant human Bone Morphogenetic Protein-2rhBMP-2rhBMP2rhBMP 2DWP401DWP-401DWP 401
02
Targets
BMPR2 (Bone morphogenetic protein receptor type 2)BMPR1B (Bone morphogenetic protein receptor type 1B)BMPR1A (Bone morphogenetic protein receptor type 1A)
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