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dyclonine hydrochloride + polyethylene glycol
- Development stage
- Unknown
- Lead developer
- Changhai Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
dyclonine hydrochloride + polyethylene glycol is a combination regimen used for bowel preparation prior to colonoscopy. Dyclonine hydrochloride is a local anesthetic that, when administered as a mucilage, provides topical anesthesia to the gastrointestinal mucosa and acts as an anti-foaming agent to improve endoscopic visibility by reducing bubbles. Polyethylene glycol (PEG) is a high-molecular-weight osmotic laxative that facilitates bowel cleansing by increasing the water content and volume of the stool. This combination is being evaluated in Phase 4 clinical trials, notably at Changhai Hospital, to determine its efficacy in enhancing the adenoma detection rate (ADR) and improving the quality of bowel preparation for colorectal cancer screening.
- Other names
- Dyclonine Hydrochloride Mucilage + PEGDyclonine + Polyethylene GlycolDyclonine + Macrogol
02
Targets
NaV (Voltage-gated sodium channels)
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