dydrogesterone

Dydrogesterone is an orally active synthetic retroprogesterone progestogen. It is a selective agonist of the nuclear progesterone receptor and produces progesterone-like effects on the endometrium, including secretory transformation of estrogen-primed endometrium and protection against estrogen-driven endometrial hyperplasia. It is marketed principally as **Duphaston** in multiple non-US markets for progesterone-deficiency-related gynecologic and reproductive indications; country-specific labels vary. Oral dydrogesterone has also been evaluated in Phase 3 IVF luteal-support studies and in observational studies of endometriosis-related pain. ([medicines.abbott.com](https://medicines.abbott.com/product/duphaston/))

Brand names

Duphaston

Other names

6-dehydroretroprogesterone6-dehydro-9beta,10alpha-progesteroneisopregnenonehydrogesterone(9beta,10alpha)-pregna-4,6-diene-3,20-dione