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Dynamized estrogen is an investigational homeopathic preparation of 17-beta-estradiol developed by researchers at the University of São Paulo General Hospital. It is produced through the homeopathic process of potentization, which involves serial dilution and succussion to reach ultra-diluted potencies of 12cH, 18cH, and 24cH. The preparation is administered as oral drops in a 30% hydroalcoholic solution. It was specifically evaluated in a Phase 4 clinical trial for the management of chronic pelvic pain in women with endometriosis who were refractory to conventional hormonal treatments. The therapy is based on homeopathic principles, aiming to stimulate a healing response rather than acting through direct pharmacological receptor modulation typical of conventional small molecule drugs.
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