dynorphin 1-13

Dynorphin 1-13 is an endogenous opioid peptide consisting of the first 13 amino acids of the full-length dynorphin A sequence. Its structure is H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH, making it a tridecapeptide[3][2]. Dynorphin 1–13 acts as a highly potent agonist at opioid receptors, with a strong preference for the kappa-opioid receptor. It is approximately 700 times more potent than [Leu]enkephalin in certain tissue assays and about three times more potent in others[5][1]. Its effects are fully blocked by naloxone, confirming its action through opioid receptors. The peptide plays roles in pain modulation, addiction, and mood regulation via activation of kappa-opioid receptors[6][7]. It also contains the [Leu]enkephalin sequence within its N-terminal region.

Other names

Dyn A (1-13)porcine dynorphin A (1-13)human dynorphin A (1-13)