dynorphin A 1-13

Dynorphin A 1-13 is a 13-amino acid endogenous peptide derived from the proteolytic cleavage of dynorphin A (1-17). It functions as a potent and selective agonist of the **kappa-type opioid receptor (KOR)**. In preclinical research, dynorphin A 1-13 has demonstrated significant physiological effects, including neuroprotection in models of cerebral ischemia (stroke) and pulmonary arterial relaxation in models of hypoxic pulmonary hypertension. It also appears to modulate immune function by enhancing lymphocyte proliferation and interleukin-2 production. Additionally, dynorphin A 1-13 is known to be a high-affinity substrate for **angiotensin-converting enzyme 2 (ACE2)**, which efficiently hydrolyzes the peptide, suggesting a regulatory link between the opioid and renin-angiotensin systems. It is primarily utilized as a pharmacological tool in the study of G protein-coupled receptor signaling and opioid biology.

Other names

Dynorphin A (1-13)Dynorphin A-(1-13)Dynorphin A1-13