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E-PRF + ACS + rhBMP-2-University of Alabama at Birmingham

Development stage: Preclinical
Lead developer: University of Alabama at Birmingham
Modality: Recombinant Proteins and Enzymes
Administration: Topical

Overview

E-PRF + ACS + rhBMP-2-University of Alabama at Birmingham is an experimental research combination consisting of Enhanced Platelet-Rich Fibrin (E-PRF), an Absorbable Collagen Sponge (ACS), and recombinant human Bone Morphogenetic Protein-2 (rhBMP-2). Developed at the University of Alabama at Birmingham, this system is designed as a dual-scaffold delivery vehicle for rhBMP-2, a potent osteoinductive biologic. E-PRF is an autologous blood-derived fibrin matrix, while ACS is a standard collagen-based carrier. The combination is intended to optimize the release kinetics of rhBMP-2, which stimulates bone formation by inducing the differentiation of mesenchymal stem cells into osteoblasts. The research, associated with trial NCT04670965, primarily involves in vitro laboratory analysis to compare the growth factor release profiles of this novel scaffold system against standard carriers for applications in bone regeneration and oral surgery.

Other names: E-PRF/ACS/rhBMP-2E-PRF + ACS + rhBMP-2Enhanced Platelet-rich fibrin + Absorbable Collagen Sponge + recombinant human Bone Morphogenetic Protein-2

Targets

BMPR2 (Bone morphogenetic protein receptor type II)BMPR1ABMPR1B

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