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E. spiculifolia extract is a methanol-aqueous botanical extract derived from the aerial parts of *Erica spiculifolia* Salisb., commonly known as Balkan heath. This evergreen shrub, native to the mountain shrublands of Eastern Europe, has traditionally been utilized as a diuretic, anti-inflammatory, and antioxidant herbal remedy. Phytochemical analysis reveals a complex composition of approximately 54 secondary metabolites, including phenolic acids (such as gallic and protocatechuic acids), flavonoids, and triterpene acids (such as oleanolic acid). Preclinical research has demonstrated that the extract possesses significant antineoplastic activity, showing selective cytotoxicity against various human malignant cell lines, including myeloid leukemia (LAMA-84) and triple-negative breast carcinoma (MDA-MB-231). The antitumor effects are attributed to the synergistic action of its bioactive constituents, particularly gallic and oleanolic acids.
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