Drug intelligence / Profile preview

East China Normal Univ. EP4 receptor compound 47

Development stage
Preclinical
Lead developer
华东师范大学
01

Overview

East China Normal Univ. EP4 receptor compound 47: sourced facts only. name: "The most promising compound 47 exhibited good EP4 antagonistic activity and excellent subtype selectivity, as well as favorable drug-like properties." [PMID:35640059]; target: "The most promising compound 47 exhibited good EP4 antagonistic activity and excellent subtype selectivity, as well as favorable drug-like properties." [PMID:35640059]; developer: "Drug Discovery Unit, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China." [PMID:35640059]; stage: "Meanwhile, oral administration of compound 47, alone or in combination with anti-PD-1 antibody, significantly enhanced the antitumor immune response and inhibited tumor growth in the mouse CT26 colon carcinoma model." [PMID:35640059]

02

Targets

PTGER4 (Prostaglandin E2 receptor EP4 subtype)

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