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Drug intelligence / Profile preview
EB-MF-CAR-NK-01
- Development stage
- Phase 2
- Lead developer
- Beijing Biotech
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Locoregional
01
Overview
EB-MF-CAR-NK-01 is an investigational allogeneic chimeric antigen receptor (CAR) natural killer (NK) cell therapy developed by Beijing Biotech. It is engineered to simultaneously target Mesothelin (MSLN), which is highly expressed on tumor cells, and Fibroblast Activation Protein (FAP), which is expressed on tumor-associated stroma. This dual-targeting approach is designed to overcome the immunosuppressive tumor microenvironment and enhance antitumor efficacy in solid tumors. The therapy is currently being evaluated in Phase 1/2 clinical trials for the treatment of unresectable, recurrent, or refractory pleural or peritoneal mesothelioma, administered via locoregional infusion following lymphodepleting chemotherapy with fludarabine and cyclophosphamide.
02
Targets
FAP (Fibroblast activation protein alpha)Mesothelin
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