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EB-OK
- Development stage
- Unknown
- Lead developer
- EpiBone
- Modality
- Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Implantable Devices → Device-based Delivery → Drug Delivery Systems, Stem Cell Therapies → Cell Therapies, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Surgical Implantation
01
Overview
EB-OK is an autologous tissue-engineered osteochondral graft developed by EpiBone for the treatment of full-thickness cartilage and bone defects in the knee. The product is manufactured by harvesting a patient's own adipose-derived stem cells and seeding them onto a decellularized bovine bone scaffold that has been precision-milled to match the patient's specific defect using CT imaging. This construct is then matured in a specialized bioreactor where the stem cells differentiate into chondrocytes and osteoblasts, forming a living, anatomically correct bone-and-cartilage graft. Upon surgical implantation, the graft is designed to biologically integrate with the host tissue, providing a permanent regenerative solution for osteochondritis dissecans or traumatic injuries, potentially avoiding or delaying the need for total joint replacement.
- Other names
- autologous engineered osteochondral tissueEpiBone Osteochondral KneeEpiBone-OK
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