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EBP11-F4
- Development stage
- Unknown
- Lead developer
- Entera Bio
- Modality
- Peptides
- Administration
- Oral
01
Overview
EBP11-F4 is an investigational oral formulation of human parathyroid hormone (1-34), also known as teriparatide, developed by Entera Bio using its proprietary oral delivery technology. This technology is designed to enable the oral administration of large molecules and peptides by utilizing a synthetic absorption enhancer to facilitate transport across the intestinal wall and a protease inhibitor to prevent degradation by digestive enzymes. EBP11-F4 is being evaluated in clinical trials for conditions requiring PTH replacement or bone-building therapy, including hypoparathyroidism, osteoporosis, and bone fractures. As an agonist of the parathyroid hormone receptor 1 (PTH1R), it regulates calcium and phosphate homeostasis and promotes bone formation by stimulating osteoblast activity.
- Other names
- oral hPTH(1-34) formulation F4
02
Targets
PTH1R (Parathyroid hormone/Parathyroid hormone-related peptide receptor type 1)
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