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EBV-specific cytotoxic T lymphocytes (Baylor College of Medicine)
- Development stage
- Phase 1
- Lead developer
- Baylor College of Medicine
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Tumor-Infiltrating Lymphocytes (TILs) → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
EBV-specific cytotoxic T lymphocytes (EBV-CTLs) are an investigational autologous cell therapy developed by Baylor College of Medicine for the treatment of Epstein-Barr virus (EBV)-associated malignancies. The therapy involves the ex vivo expansion of a patient's own T cells, which are primed to recognize and eliminate cells expressing EBV-specific antigens, specifically Latent Membrane Protein 1 (LMP1) and Latent Membrane Protein 2 (LMP2). These viral proteins are frequently expressed in EBV-positive Hodgkin lymphoma, non-Hodgkin lymphoma, and certain plasma cell neoplasms. By restoring or enhancing the host's cellular immune response against these viral targets, the therapy aims to induce tumor regression in patients with relapsed or refractory disease. Early clinical iterations of this therapy at Baylor utilized neomycin resistance gene marking to track the persistence and localization of the infused CTLs in vivo.
- Other names
- Autologous EBV-specific cytotoxic T lymphocytesNeomycin Resistance Gene Marked EBV Specific Cytotoxic T-LymphocytesEBV-specific CTLsLMP-specific cytotoxic T lymphocytes
02
Targets
LMP1-YLLEMLWRL-HLA-A2 (Epstein-Barr virus Latent Membrane Protein 1 (LMP1) peptide YLLEMLWRL presented by HLA-A*02:01)LMP1-YLQ/HLA-A2 (Epstein-Barr virus latent membrane protein 1 peptide YLQQNWWTL presented by HLA-A*02:01)Epstein-Barr virus latent membrane protein 2-derived peptides presented by class I human leukocyte antigen (HLA) alleles
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