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EBV-specific immune effector cells
- Development stage
- Unknown
- Lead developer
- Vectorite Biomedical
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
EBV-specific immune effector cells is an adoptive cell therapy developed by Vectorite Biomedica for the treatment and prevention of Epstein-Barr virus (EBV)-associated lymphoproliferative disorders. The therapy consists of autologous or donor-derived CD4+ and CD8+ T cells that are expanded ex vivo using a protein-spanning pool of pentadecapeptides derived from the EBV latent membrane protein 2A (LMP2A). These cells are selected based on activation markers such as IFN-γ or CD137 and stimulated with dendritic cells to enhance their specificity and potency. Once infused, these effector cells target and eliminate EBV-infected cells expressing viral antigens, particularly in the context of post-transplant lymphoproliferative disorder (PTLD).
- Other names
- EBV-specific T cellsEBV-specific CD4+ and CD8+ T cells
02
Targets
Epstein–Barr virus latent membrane protein 2A peptide-HLA class I complex
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