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Drug intelligence / Profile preview
Ec1-LoPE
- Development stage
- Preclinical
- Lead developer
- KTH Royal Institute of Technology
- Modality
- Bacterial Toxin Conjugates → Immunotoxins → Antibody Conjugates → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
- Administration
- Intraperitoneal, Intravenous
01
Overview
Ec1-LoPE is a recombinant fusion protein consisting of the epithelial cell adhesion molecule (EpCAM)-targeting designed ankyrin repeat protein (DARPin) Ec1 fused to a low-immunogenicity variant of Pseudomonas exotoxin A (LoPE). It is designed to selectively bind to EpCAM-expressing cancer cells, undergo receptor-mediated endocytosis, and deliver the cytotoxic toxin payload to inhibit protein synthesis and induce cell death. Ec1-LoPE has been investigated in preclinical studies for the treatment of various EpCAM-expressing malignancies, including ovarian cancer, prostate cancer, pancreatic cancer, and breast cancer, both as a monotherapy and in combination with other targeted therapies such as trastuzumab or seribantumab.
- Other names
- DARPin Ec1-LoPEEC1-LoPEEC-1-LoPEEC 1-LoPEEc1-LoPE fusion proteinEc-1-LoPE fusion proteinEc 1-LoPE fusion protein
02
Targets
EPCAM (Epithelial cell adhesion molecule)
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