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eccMIR144/451C
- Development stage
- Preclinical
- Lead developer
- Peking University
- Modality
- Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
eccMIR144/451C is a synthetic extrachromosomal circular DNA (eccDNA) carrying the hsa-mir-144/451 cluster [Sa1212]. Developed by researchers at Peking University, it is designed to suppress innate immune activation in chronic atrophic gastritis (CAG) and prevent its progression to gastric cancer [Sa1212]. Synthesized using the GALA method, eccMIR144/451C is efficiently transcribed to produce precursor miRNAs, leading to elevated levels of miR-4732-5p [Sa1212]. This miRNA directly targets and downregulates 2'-5'-oligoadenylate synthetase-like protein (OASL), thereby suppressing downstream interferon-stimulated genes (such as ISG15, MX2, and IFIT1) and inhibiting cell proliferation while increasing alkaline phosphatase activity [Sa1212].
- Other names
- eccDNA carrying the hsa-mir-144/451 clusterextrachromosomal circular DNA carrying the hsa-mir-144/451 cluster
02
Targets
OASL
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