Drug intelligence / Profile preview

echinacea purpurea flower extract

Development stage
Unknown
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Echinacea purpurea flower extract is a botanical extract derived from the flowers of the purple coneflower (Echinacea purpurea). It is classified as a herbal medicine or dietary supplement and is produced by multiple manufacturers. [1] The extract contains various bioactive compounds, including alkamides, caffeic acid derivatives (such as chicoric acid and caftaric acid), and polysaccharides. [2, 5] It is primarily used for its immunomodulatory and anti-inflammatory properties. The mechanism of action involves stimulating the immune system, such as enhancing phagocytosis, and modulating the production of pro-inflammatory cytokines like TNF-α, IL-6, and IL-8. [2, 5, 13] It is commonly used to prevent or treat upper respiratory tract infections, such as the common cold, though clinical evidence is mixed. [2, 12] It is also used topically for skin conditions like eczema and to promote wound healing. [12, 15]

Other names
Echinacea purpurea flowers extractEFPurple coneflower extract
02

Targets

IL-6 (Interleukin 6)NF-κBCB (Cannabinoid receptors)TNFA (Tumor necrosis factor alpha (soluble))

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