Drug intelligence / Profile preview

echinops cephalotes aqueous extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Echinops cephalotes aqueous extract is a **plant-derived natural product extract** prepared from *Echinops cephalotes* and studied in **preclinical academic research** rather than as a branded or commercially developed pharmaceutical. Reported activities are pleiotropic and include **antioxidant, anti-inflammatory, antidiabetic, cardioprotective, neuroprotective, and antifungal effects** in animal and in vitro models. In the available literature, the extract has been investigated for protection against myocardial ischemia-reperfusion injury with modulation of **matrix metalloproteinase 2**, **matrix metalloproteinase 9**, and **tissue inhibitor of metalloproteinase 1** signaling, reduction of oxidative stress, improvement of glucose dysregulation and pancreatic islet changes in diabetes models, and reversal of scopolamine-induced memory impairment consistent with **acetylcholinesterase** and **butyrylcholinesterase** inhibitory activity. The agent remains a heterogeneous botanical research extract with incompletely defined active constituents, no identified commercial developer, no established brand name, and no clinical-stage development program.

Other names
Echinops cephalotes aqueous extractaqueous extract of Echinops cephalotesEC aqueous extract
02

Targets

MMP9 (Matrix metalloproteinase-9)ButyrylcholinesteraseTIMP1 (Metalloproteinase inhibitor 1)MMP2 (Matrix metalloproteinase-2)Acetylcholinesterase

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