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eciskafusp alfa
- Development stage
- Phase 1
- Lead developer
- Roche
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Immunomodulatory ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous, Intravesical
01
Overview
Eciskafusp alfa is a recombinant fusion protein immunocytokine that combines an interleukin-2 variant (IL2v) with an anti-PD1 protein moiety. It is designed to preferentially target PD-1–expressing T cells, particularly antigen-specific stem-like PD-1+ TCF-1+ CD8+ T cells, expanding and differentiating them into more effective effector T cells. The IL2v component stimulates local immune responses by activating natural killer (NK) cells and cytotoxic T lymphocytes, while the anti-PD1 moiety blocks the programmed cell death 1 receptor (PD‑1), enhancing antitumor immunity. Eciskafusp alfa is being developed primarily for advanced or metastatic solid tumors responsive to checkpoint inhibition blockade and has also entered trials for non-muscle invasive bladder cancer in combination with Bacillus Calmette–Guérin (BCG). The drug was originated and is being developed by Roche/Hoffmann-La Roche[3][8][2][4].
- Other names
- eciskafusp alfa
02
Targets
IL2RA (Interleukin-2 receptor alpha subunit)PDCD1 (Programmed cell death protein 1 receptor)IL2RB (IL-2 receptor beta chain)
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