Drug intelligence / Profile preview

econazole nitrate topical foam

Development stage
Approved
Lead developer
Resilia Pharmaceuticals
Modality
Small Molecules
Administration
Topical
01

Overview

Ecoza is a brand name for econazole nitrate topical foam, an azole antifungal medication. It is indicated for the treatment of interdigital tinea pedis (athlete’s foot) caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum in patients 12 years of age and older. Econazole works by inhibiting fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylase enzyme, which disrupts ergosterol synthesis in the fungal cell membrane. This leads to accumulation of toxic sterols and loss of membrane integrity, resulting in fungistatic activity. The product is supplied as a 1% topical foam and should be applied once daily for four weeks[1][2][4][5].

Brand names
EcozaSpectazole
Other names
econazole nitrate topical foameconazole topical
02

Targets

CYP51A1 (Sterol 14α-demethylase)

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