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ECT-001-expanded cord blood
- Development stage
- Unknown
- Lead developer
- ExCellThera
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
ECT-001-expanded cord blood is an ex vivo expanded allogeneic cell therapy derived from a single umbilical cord blood (UCB) unit. The expansion process utilizes UM171, a small molecule agonist that promotes the self-renewal of hematopoietic stem cells (HSCs) while preventing their differentiation. The final product consists of UM171-expanded CD34+ hematopoietic stem and progenitor cells (HSPCs) combined with the unexpanded CD34- fraction from the same donor unit. Administered intravenously, ECT-001 is designed to provide rapid and robust engraftment in patients undergoing hematopoietic stem cell transplantation (HCT), particularly those with high-risk myeloid malignancies who lack a suitable matched donor. It has received conditional marketing authorization in the European Union under the brand name Zemcelpro for certain hematologic conditions.
- Brand names
- Zemcelpro
- Other names
- UM171-expanded cord bloodUM-171-expanded cord bloodUM 171-expanded cord bloodexpanded umbilical cord blood
02
Targets
CD34 (CD34 antigen)
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