Drug intelligence / Profile preview

ectoine + hyaluronic acid

Development stage
Phase 4
Lead developer
URSAPHARM Arzneimittel
Modality
Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Small Molecules, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
Administration
Topical, Sublingual, Ophthalmic
01

Overview

**Ectoine + hyaluronic acid** is a non-systemic topical combination used in ocular-lubricating preparations and investigated in dermatologic cream formulations. Ectoine is a natural extremolyte with water-binding and membrane-stabilizing properties, while hyaluronic acid forms a bioadhesive, water-retaining lubricating film. In marketed HYLO ocular formulations, the combination hydrates the corneal and conjunctival surface, stabilizes the tear film and reduces tear evaporation, helping relieve dry-eye irritation and allergy-associated ocular symptoms. A 1% ectoine plus 0.1% hyaluronic acid cream has also been studied in children with mild-to-moderate atopic dermatitis.

Brand names
HYLO DUALHYLO DUAL INTENSE
Other names
ectoin + hyaluronic acidEHA creamhyaluronic acid + ectoine透明質酸 + ectoin

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