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edetate calcium disodium
- Development stage
- Approved
- Lead developer
- Rising Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Intravenous, Intramuscular
01
Overview
Edetate calcium disodium is a small molecule chelating agent primarily indicated for the reduction of blood lead levels and the treatment of lead poisoning. In clinical research led by **Chang Gung Memorial Hospital**, it has been investigated for its potential to slow the progression of **chronic renal insufficiency** in non-diabetic patients who possess a high-normal body lead burden. The drug functions by binding to divalent and trivalent heavy metals—most notably lead—to form stable, water-soluble complexes that are subsequently eliminated from the body via urinary excretion. The therapeutic rationale in renal disease is based on the hypothesis that reducing cumulative lead exposure can mitigate chronic lead-induced nephrotoxicity and preserve glomerular filtration rates over time.
- Brand names
- Calcium Disodium Versenate
- Other names
- calcium disodium EDTACaNa2EDTACaNa-2EDTACaNa 2EDTAedetate calciumcalcium EDTA
02
Targets
CD2 (T-cell Surface Antigen CD2)Fe3+ (Ferric iron)PB2 (Influenza PB2)Zn2+ (Zinc ion)
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