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Edivoxetine is a highly selective norepinephrine reuptake inhibitor (NRI) developed by Eli Lilly. It was investigated as a treatment for major depressive disorder (MDD), attention-deficit hyperactivity disorder (ADHD), and anxiety disorders. Edivoxetine acts by selectively inhibiting the reuptake of norepinephrine in the central nervous system, thereby increasing its synaptic concentration. The drug reached phase III clinical trials for MDD but failed to demonstrate sufficient efficacy compared to standard treatments and was discontinued for this indication in 2013. Development continues for ADHD, where it is being studied as both adjunctive and monotherapy. Edivoxetine is administered orally and has a pharmacokinetic profile characterized by rapid absorption (Tmax ~2 hours) and a half-life of approximately 4–6 hours[1][2][3][5][7].
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