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EF-011

Development stage: Preclinical
Lead developer: Everfront Biotech
Modality: Small Molecules

Overview

EF-011 is an investigational small molecule drug developed by Everfront Biotech for the treatment of idiopathic pulmonary fibrosis (IPF). It works by inhibiting the binding of SOX2 to the promoter of type I collagen, thereby reducing the expression and accumulation of type I collagen, which is involved in fibrosis formation. In preclinical studies, EF-011 showed significant improvement in tissue pathology and respiratory function compared to pirfenidone.

Targets

SRY-box transcription factor 2–DNA complex at the type I collagen promoter

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